Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism

Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism

The impressive impact of cisplatin on cancer on one side and severe side effects, as well as the development of drug resistance during treatment on the other side, were the factors motivating scientists to design and synthesize new more potent analogues lacking disadvantages of cisplatin. Platinum(IV) complexes represent one of the perspective groups of platinum-based drugs. In this review, we ...

Anticancer metal complexes and tumour targeting strategies

Metabolism of the unnatural anticancer lipid safingol,

We studied the metabolism of radioactively labeled safingol ( L threodihydrosphingosine) in primary cultured neurons, B104 neuroblastoma cells, and Swiss 3T3 fibroblasts, and compared it to that of its natural stereoisomer D erythro -dihydrosphingosine. Both sphingoid bases are used as biosynthetic precursors for complex sphingolipids, albeit to different rates. Whereas a considerable amount of...

Antioxidant properties of vanadium complexes and their anticancer effects on human gastric cancer cell line MKN45

Introduction: Gastric cancer is the fourth most common cancer worldwide and the second leading cause of death from cancer. In recent years, advances in cancer therapy have raised the specter of developing effective agents of high-impact diseases, like gastric cancer, which remains one of the major causes of cancer deaths in the world. Recently it has been demonstrated that vanadium compounds ex...

Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

Over the last decades, several studies have demonstrated that cancer cells have a unique metabolism compared to normal cells (Herling et al., 2011). Metabolic changes occurring in cancer cells are considered to be fundamental for the transformation of normal cells into cancer cells and are also responsible for the resistance to different types of chemotherapeutic drugs (Cree, 2011). Therefore, ...